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THE BIOMANUFACTURING PROCESS


Army’s DEVCOM Chemical Biological Center collaborates with research lab partners, like the DEVCOM Army Research Laboratory, to scale up biomanufacturing processes for high-value materials, with the goal of transitioning those processes to industry for bulk production for national defense applications. (Graphic by Anna Crumbley, Ph.D., and Addie Huynh, DEVCOM Chemical Biological Center)


thrive inside the vats. Tis includes placing them in the right- sized vats at the right time and placing just the right mixtures of salts and sugars in the vats. Tey optimize aeration and mixing inside the vats to keep the microbials producing the new material consistently and in large quantities. Te team seeks to maximize each strain’s ability to precisely create the material it was designed to produce and do it with the greatest yield possible.


Te biomanufacturing team also works with DEVCOM Chem- ical Biological Center engineers to devise the best way to extract these new materials from the vats, which are full of nutrient soup. To do this, the center pulls together a project team of profession- als from across the organization to create the right mix of skills


16 Army AL&T Magazine Fall 2023


and knowledge. Troughout the process, from strain discovery and process optimization to full-scale production, information flows between the DEVCOM teams involved. Tis shared knowl- edge enables them to continuously make improvements to the process. Te result is that when the Army hands off the scaled- up process to its industry partners for commercial production, those partners get an optimized organism and an optimized production process.


BETTER EQUIPPED WARFIGHTERS Everything that DEVCOM Chemical Biological Center and DEVCOM Army Research Laboratory scientists and engi- neers do to support the biomanufacturing facility is with the


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