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ARMY AL&T


SYSTEM OF SYSTEMS


The VAMP program takes a system-of-systems approach to vaccine delivery. By breaking down vaccines into their individual systems (e.g., adjuvants, payload delivery type, delivery method), each system can be individually advanced as part of a collective vaccine prototype. Doing so allows for rapid advancement of both vaccine components and vaccine platforms specific to warfighter needs. (Graphic by JPM CBRN Medical)


program as it undertook the selection of performers. Namely, that when it comes to vaccines, there is no single-best technology for vaccine design; the best technology is the one that works for a given threat. A second motif during selection was that design- ing novel vaccines one at a time from scratch cannot keep up with the speed of nature. A balance of cutting-edge technologies and tried-and-true vaccine backbones were selected for further development. However, the foundational concept shared by all VAMP performers is an emphasis on vaccine platform technol- ogies creating system-of-systems prototypes.


Vaccine platforms act as the rolling body and turret of a tank. As tanks are produced, the body and turret largely remain the same, and can be deployed to counter an array of battlefield threats. Different threat-specific ordnance (e.g., armor piercing, high explosive) can then be selected to address each individual target, without changing the overall design of the tank. For vaccine platforms, the basic vaccine components and antigen carrier of the platform remain the same regardless of threat, just like the body and turret of the tank. Similar to threat-specific shells, the antigenic design of platforms, or the pieces of the vaccine


construct that train the immune system on what to prepare for, can be modified to target-specific threats without changing over- all vaccine design.


Just like platform vaccines support the insertion of various anti- gens to target differing threats, the system of systems that make up a platform vaccine can support interchangeability of vari- ous vaccine components to optimize a vaccine for a specific use. For example, deliberate alteration of the delivery method of a vaccine can tailor use for warfighter needs by allowing easier vaccine administration, or through improvement of cold chain storage and stability.


Although each performer will design and test a candidate vaccine for a specific threat or threat family, the overall objective of the program is to advance the underlying platforms and systems upon which the vaccine is built for DOD to employ as part of the warfighter’s complete biological armor. Te performers with whom agreements were recently awarded represent a diversity of platform technologies.


https://asc.ar my.mil


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