A SYSTEMATIC APPROACH


hosted at the Uniformed Services Univer- sity, highlighted the center’s whole-genome sample processing and computational capabilities, which are unparalleled within DOD. Currently, the center has 18 genetic sequencers that include state-of-the-art technology. With more than 80 ongoing projects across DOD and collaborations at the National Institutes of Health, the center is helping to assess genetic risks for illnesses like cardiovascular disease and cancer to improve diagnosis and treatment.


KEYNOTE ADDRESS


Dr. Marti Jett, Army chief scientist for systems biology, presents the keynote “Evolution of Systems Biology within USAMRMC” at the workshop. (Photo by USAMRMC Public Affairs)


In a time when doing more with less is the mantra and fiscal responsibility is more important than ever, this inclusive meet- ing was pivotal for bringing together those with shared interests and, more impor- tantly, shared goals. It also served as a jumping-off point to ensure continued efficiency by identifying gaps and barri- ers across the myriad integrative biology research efforts.


“ 30


This integrative approach to


biomedical research provides us an


opportunity to get to a level of complexity that we have never been able to get to before.


One outcome of the meeting was to initiate collaborations that will lead to expedited delivery of tools and solutions. Further, it is anticipated that biomedi- cal research study designs will be more comprehensive as a result of the accessibil- ity and knowledge of supporting research and engineering capabilities across DOD.


” Army AL&T Magazine Spring 2019


Workshop attendees were impressed to learn about the breadth of work and technologies throughout the enterprise. Attendees appreciated the opportu- nity to see how computational analysis is being applied across a wide range of DOD biomedical research. Addition- ally, they benefited from seeing targeted, multidimensional studies that integrate several approaches focused on medical application.


In fact, in a survey of workshop attend- ees, 68 percent of respondents indicated they learned about a new technology, data


type or methodology during the workshop. From the Biotechnology High Perfor- mance Computing Software Applications Institute’s capabilities in the development of machine-learning based algorithms, to the U.S. Army Medical Research Insti- tute of Infectious Diseases’ rapid genomic sequencing for disease surveillance, the diversity of possibilities encouraged partic- ipants to pursue collaborations.


HANDS-ON TECH Scientific capabilities developed to promote data collection and collabora- tion were on display during the working lunch on Nov. 29. Attendees participated in product demonstrations and learned more about how USAMRMC capabili- ties could improve the efficiency of current and future research efforts. Tese capabil- ity demonstrations included:


• USAMRMC’s SysBioCube, which functions as an integrated biomedi- cal research data access, management and analysis platform for biomedical research of military relevance. It serves as a central portal for data collection, harmonization, mining and file sharing, and is accessible to all members of the DOD research community, including extramural partners.


• 2B-Alert, developed by the Biotech- nology High Performance Computing Software Applications Institute. It is a smartphone app that uses sleep-wake and caffeine schedules and measure- ments of past performance (including results from the psychomotor vigilance test) to predict alertness and cogni- tive performance. The system allows users to input additional data parame- ters, and lets users or commanders view predicted cognitive performance levels at desired times.


• PanoramiX, a platform developed by the Integrative Systems Biology Program at the U.S. Army Center for


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