ARMY AL&T
Environmental Health Research that enables researchers to visualize the interconnectedness of tailored genome assays with pathological networks and phenotypes for cells or organisms in a data-agnostic manner. This tool allows researchers to easily explore genomic data sets, which tend to be large and difficult to manage, in order to iden- tify interactive networks.
• Functional Heatmap, made by the same group that developed Panora- miX. It is an automated and interactive tool enabling pattern recognition in time-series data, providing a means for researchers to identify trends driven by functional changes. This tool translates numerical data, generally from data sets that are very large and cumbersome to manually evaluate, into color-defined visualizations, allowing researchers to more easily identify patterns.
DISCUSSING THE WAY FORWARD Te workshop closed with a panel discus- sion driven by questions that arose during the two-day event. Te group discussed the greatest opportunities for integra- tive biomedical research as well as the potential to develop disruptive medical
capabilities that could change the land- scape of force readiness by improving warfighter lethality.
Participants also discussed the extensive bureaucratic inhibitors that delay the establishment of collaborations as well as barriers that prevent effective data sharing, such as concerns about intellec- tual property and data rights. Tere was unquestionable agreement that collabo- ration is essential to avoid duplication of efforts.
Leadership echoed the need for a team approach in support of the warfighter.
“We are all working on the same puzzle,” said Dr. Ben Petro, acting director of the Office of the Undersecretary of Defense for Research and Engineering. “But you all are working on a puzzle that has millions of pieces. If we are working on the same puzzle, how should we organize ourselves strategically?”
Petro continued, “Reach out to others working on a puzzle and figure out how the piece I’m working on provides [clues] to the larger puzzle. As we find pieces that can help other people, we are sharing. Te puzzle is a holistic view of the warfighter
across all activities and all health states. Te opportunity I see here is convergence.”
Dr. William Mattes, director of the Divi- sion of Systems Biology at the U.S. Food and Drug Administration’s National Center
for Toxicological Research, discussed the topic of standardization.
“When I think of integrative biomedical research, one of the things that catapulted the genomic field was standardizing the data files,” he said. “We need to force some standardization, and there are so many opportunities there. It makes it more effi- cient. Ten you aren’t duplicating efforts, you are synergizing efforts.”
Efficiency is extremely important, said Maj. Jonathan Stallings, acting direc- tor of USAMRMC’s Office of Regulated Activities. “We should talk about standard- ization up front,” he said. “Collectively, we need to pull minds together and decide what standardization looks like. Tis would allow us to deliver efficiency in a time when money is precious.”
Working together will allow teams to bring ideas to fruition more quickly, according to Dr. George Ludwig, princi- pal assistant for research and technology
INNOVATIVE MILITARY RESEARCH
Dr. Robert Green, professor of medicine at Harvard Medical School and director of the Genomes2People Research Program at Brigham and Women’s Hospital and Broad Institute, presents “The MilSeq Project: Enabling Personalized Medicine through Exome Sequencing in the U.S. Air Force” at the workshop. This work is funded by the U.S. Air Force. (Photo by USAMRMC Public Affairs)
https://asc.ar my.mil
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